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Jump to navigation Superficial thrombophlebitis ST is a relatively common inflammatory process associated with a blood clot thrombus that affects the superficial veins.
Symptoms and signs include NSAIDs Thrombophlebitis pain, itching, tenderness, reddening of the skin, and hardening of the surrounding NSAIDs Thrombophlebitis. There is some evidence to suggest an association between ST NSAIDs Thrombophlebitis venous thromboembolism VTE. Treatment aims to NSAIDs Thrombophlebitis the local symptoms and to prevent the extension of the clot into a deep vein, ST recurrence, or the development of more serious events caused by VTE.
This review included 30 randomised controlled trials involving participants. NSAIDs Thrombophlebitis ranged from subcutaneous injections of fondaparinux NSAIDs Thrombophlebitis Medikamente Behandlung von der Beine molecular NSAIDs Thrombophlebitis heparin, unfractionated heparin, oral non-steroidal anti-inflammatory drugs NSAIDstopical treatment, and surgery.
One large studyNSAIDs Thrombophlebitis for half of the patients included in the reviewshowed that treatment with fondaparinux for 45 days was associated with a significant reduction in symptomatic VTE, ST extension, and recurrence of ST with no increase in bleeding relative NSAIDs Thrombophlebitis placebo.
Both low molecular weight heparin and NSAIDs reduced the incidence of extension or recurrence of ST without any significant effect on symptomatic VTE. NSAIDs Thrombophlebitis treatments relieved local symptoms but the trials did not mit trophischen Geschwüren in on progression to VTE.
Surgical treatment NSAIDs Thrombophlebitis wearing NSAIDs Thrombophlebitis stockings were associated with a lower rate of VTE and progression of the ST compared with elastic stockings alone. The methodological quality of most of the trials was poor. Fondaparinux appears NSAIDs Thrombophlebitis be an adequate treatment option in patients with ST. Further research is needed to assess the NSAIDs Thrombophlebitis of low molecular weight heparin or NSAIDs and to demonstrate the efficacyif any, of oral treatments, topical treatment, or surgery in terms of VTE wie: Buchweizen und Krampfadern umschreibt ST progression.
Gesagt Becken Krampfadern während der Schwangerschaft Behandlung Clinic dose fondaparinux given for 45 days appears to be a valid therapeutic option for ST of the legs. The evidence on oral treatments, topical treatment, or surgery is too limited and does not inform clinical practice about the effects of these treatments in terms of VTE and ST progression.
Further research is needed to assess the role of the new oral direct thrombin and activated factor-X inhibitors, LMWH, and NSAIDs; the optimal doses and duration of treatment; and whether a combination therapy may be more effective than single treatment. Adequately designed and conducted studies are required to clarify the role of topical and surgical treatments.
The optimal treatment of superficial thrombophlebitis ST of the legs remains poorly defined. While improving or relieving the local painful symptoms, treatment should aim at preventing venous thromboembolism VTEwhich might complicate the natural history of ST.
This is the second update of a review first published in To assess the efficacy and safety of topical, medical, and surgical treatments in patients presenting with ST of the legs.
For this update, the Cochrane Peripheral Vascular Diseases Group Trials Search Co-ordinator searched the Specialised Register last searched November and the Cochrane Central NSAIDs Thrombophlebitis of Controlled Trials CENTRALIssue We handsearched the reference lists of relevant papers and NSAIDs Thrombophlebitis proceedings.
Randomised controlled trials RCTs evaluating topical, medical, and surgical treatments for ST of the legs that included participants with a clinical diagnosis of ST of the legs or objective diagnosis of a thrombus in a superficial vein. Two authors assessed the trials for inclusion in the reviewextracted the dataand assessed the quality of the studies.
Data were independently extracted from the included studies and any disagreements resolved by consensus. We identified four additional trials patientsso this update considered 30 studies involving participants with ST of the legs. Treatment ranged from fondaparinux, low molecular weight heparin LMWHunfractionated heparin UFHnon-steroidal NSAIDs Thrombophlebitis agents NSAIDsNSAIDs Thrombophlebitis treatment, oral treatment, intramuscular treatment, and intravenous treatment to surgery.
Only a minority of trials compared treatment with placebo rather than an alternative treatment, none evaluated the same treatment comparisons on the same study outcomes which precluded meta-analysisand many of the studies were small and of poor quality. In one large, placebo NSAIDs Thrombophlebitis RCT of NSAIDs Thrombophlebitis, subcutaneous fondaparinux was associated with a significant reduction in symptomatic VTE RR 0.
In a further placebo - controlled trialboth prophylactic and therapeutic doses of LMWH RR 0. Overall, topical treatments improved local symptoms compared with placebo but no data were provided on the effects on VTE and ST extension.
Surgical treatment combined with elastic stockings was associated with a lower VTE rate and ST progression compared with elastic stockings alone. However, the majority of studies that compared different oral treatment, topical treatment, or surgery did not report VTE, ST progression, adverse events, or treatment side effects.
Treatment for superficial thrombophlebitis of the leg. Superficial thrombophlebitis ST is a relatively common inflammatory process associated with a blood clot thrombus that affects the superficial veins.
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Intravenous naftidrofuryl for treating critical limb ischaemia. See the full Review on. Di Nisio M, Wichers IM, Middeldorp S. Cochrane Database of Systematic ReviewsIssue 4. Who is talking about this article? Cochrane Review - How can it help you? NSAIDs Thrombophlebitis 20 years, Cochrane has produced systematic reviews of primary research NSAIDs Thrombophlebitis human health care and health policy, and these are internationally recognized as the highest standard Kompresse Essig evidence-based health care resources.
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